Figure 4.

Analysis of the inter-relationships between non-malignant B cell cluster frequency and Binet stages. (A) Clusters have been organized and grouped according to the B cell developmental stage they belong to. The color of the circles corresponds to the correlation (red for positive, blue for negative) and the stars and size of the circles indicate the degree of significance of the correlation (*p < 0.05, **p < 0.01). (B) Box and whisker plots illustrating the frequencies of the clusters which abundance is correlated with Binet stage C in stage A, B and C patients. Statistical significancy was estimated with the Mann-Whitney U test. The p values are indicated on the graphs. P values of <0.05 were considered as statistically significant and are identified in red.