Table 3.
Differences in Adverse Reactions of Live-Attenuated Oxford/AstraZeneca COVID-19 Vaccination Between Hypertension (n=616) and Non-Hypertension (n=2400) Groups
| Sign effect | Category | 1st Dose | 2nd Dose | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hypertension (n=616) | Non-Hypertension (n=2400) | RR (95% CI) | p-value | Hypertension (n=616) | None Hypertension (n=2400) | RR (95% CI) | p-value | ||
| n(%) | n(%) | n(%) | n(%) | ||||||
| Within 30 minutes | Fever, mild headache or high grade fever, severe headache | 9(1.5) | 29(1.2) | 1.2 (0.575to2.514) | 0.616 | 1(0.2) | 1(0.01) | 3.9 (0.244to62.20) | 0.336 |
| Chest discomfort or breathing difficulties | - | - | - | - | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 0(0) | 5(0.2) | -- | - | - | - | - | - | |
| Skin rash /urticaria | 1(0.2) | 6(0.2) | 0.8 (0.091 to 6.658) | 0.82 | 1(0.2) | 0(0) | - | - | |
| Pain, swelling, redness and warmth at the injection site | 4(0.6) | 14(0.6) | 1.1 (0.368to3.37) | 0.85 | - | - | - | - | |
| Within 6 hours | Fever, mild headache or high grade fever, severe headache | 51(8.3) | 210(8.8) | 1 (0.706 to 1.268) | 0.711 | 7(1.1) | 43(1.8) | 0.6 (0.287to1.4) | 0.26 |
| Chest discomfort or breathing difficulties | - | - | - | - | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 4(0.6) | 17(0.7) | 0.9 (0.31 to 2.715) | 0.875 | 0(0) | 3(0.1) | - | - | |
| Skin rash /urticaria | 3(0.5) | 22(0.9) | 0.5 (0.16 to 1.769) | 0.302 | 1(0.2) | 3(0.1) | 1.3 (0.135to12.46) | 0.821 | |
| Pain, swelling, redness and warmth at the injection site | 15(2.4) | 58(2.4) | 1 (0.575 to 1.765) | 0.979 | 4(0.6) | 14(0.6) | 1.1 (0.368to3.37) | 0.85 | |
| Within 24 hours | Fever, mild headache or high grade fever, severe headache | 198(32.1) | 740(30.8) | 1.1 (0.916 to 1.187) | 0.531 | 109(17.7) | 436(18.2) | 0.98 (0.805to1.178) | 0.786 |
| Chest discomfort or breathing difficulties | 2(0.3) | 1(0.001) | 7.8 (0.708 to 85.79) | 0.093 | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 7(1.1) | 58(2.4) | 0.5 (0.216 to 1.025) | 0.057 | 3(0.5) | 10(0.4) | 1.2 (0.323to4.234) | 0.812 | |
| Skin rash /urticaria | 14(2.3) | 71(3) | 0.8 (0.436 to 1.353) | 0.36 | 3(0.5) | 15(0.6) | 0.8 (0.226to2.683) | 0.692 | |
| Pain, swelling, redness and warmth at the injection site | 91(14.8) | 314(13.1) | 1.1 (0.91 to 1.401) | 0.273 | 31(5) | 150(6) | 0.8 (0.553to1.173) | 0.257 | |
| After 24 hours | Fever, mild headache or high grade fever, severe headache | 68(11) | 365(15.2) | 0.7 (0.569 to 0.926) | 0.009* | 49(8) | 251(10.5) | 0.8 (0.567to1.02) | 0.065 |
| Chest discomfort or breathing difficulties | 2(0.3) | 2(0.1) | 3.9 (0.55 to 27.603) | 0.174 | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 5(0.8) | 29(1.2) | 0.7 (0.261 to 1.728) | 0.409 | 3(0.5) | 7(0.3) | 1.7 (0.433to6.438) | 0.457 | |
| Skin rash /urticaria | 13(2.1) | 43(1.8) | 1.2 (0.637 to 2.177) | 0.602 | 3(0.5) | 15(0.6) | 0.8 (0.226to2.683) | 0.692 | |
| Pain, swelling, redness and warmth at the injection site | 32(5.2) | 183(7.6) | 0.7 (0.473 to 0.981) | 0.038* | 18(2.9) | 125(5.2) | 0.6 (0.345to0.912) | 0.019* | |
| Within 3 days | Fever, mild headache or high grade fever, severe headache | 63(10.2) | 357(14.9) | 0.7 (0.534 to 0.885) | 0.003* | 49(8) | 249(10.4) | 0.8 (0.572to1.03) | 0.073 |
| Chest discomfort or breathing difficulties | 2(0.3) | 1(0.01) | 7.8 (0.708 to 85.79) | 0.093 | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 5(0.8) | 25(1) | 0.8 (0.3 to 2.027) | 0.609 | 3(0.5) | 7(0.3) | 1.7 (0.433to6.438) | 0.457 | |
| Skin rash /urticaria | 11(1.8) | 38(1.6) | 1.1 (0.58 to 2.193) | 0.723 | 2(0.3) | 12(0.5) | 0.6 (0.146to2.894) | 0.571 | |
| Pain, swelling, redness and warmth at the injection site | 32(5.2) | 180(7.5) | 0.7 (0.481 to 0.998) | 0.047* | 18(2.9) | 123(5.1) | 0.6 (0.35to0.928) | 0.023* | |
| Within 7 days | Fever, mild headache or high grade fever, severe headache | 67(10.9) | 365(15.2) | 0.7 (0.56 to 0.914) | 0.006* | 49(8) | 251(10.5) | 0.8 (0.567to1.02) | 0.065 |
| Chest discomfort or breathing difficulties | 2(0.3) | 2(0.1) | 3.9 (0.55 to 27.603) | 0.174 | - | - | - | - | |
| Nausea or vomiting (no more than 5 times) | 5(0.8) | 27(1.1) | 0.7 (0.279 to 1.866) | 0.5 | 3(0.5) | 7(0.3) | 1.7 (0.433to6.438) | 0.457 | |
| Skin rash /urticaria | 13(2.1) | 41(1.7) | 1.2 (0.666 to 2.291) | 0.503 | 3(0.5) | 15(0.6) | 0.8 (0.226to2.683) | 0.692 | |
| Pain, swelling, redness and warmth at the injection site | 32(5.2) | 183(7.6) | 0.7 (0.473 to 0.981) | 0.038* | 18(2.9) | 125(5.2) | 0.6 (0.345to0.912) | 0.019* | |
Note: *is significance with alpha=0.05.