Table 5.
Genes investigated for a potential role in C. glabrata drug resistance, based on the genome-wide analysis of the azole resistant isolates 50570 and 73281.
| C. glabrata gene | S. cerevisiae homolog | Selection criteria |
|---|---|---|
| PEX11 | - | Peroxisomal activity |
| CAGL0A04543g | AAR2 | Altered azole susceptibility/differential expression |
| CAGL0G04169g | YDR306C | Frameshift mutation |
| CAGL0G04455g | IME2 | AmB resistance |
| CAGL0H09130g | MNN4 | Frameshift mutation |
| KES1 | - | Ergosterol biosynthesis |
| CAGL0F03003g | HKR1 | Frameshift->stop |
| CAGL0H03465g | - | Frameshift mutation |
| CAGL0I09878g | FAA1 | Lipid metabolism |
| CAGL0J00891g | LTV1 | Altered azole susceptibility/differential expression |
| CAGL0J08613g | YVC1 | Frameshift mutation |