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. 2022 Nov 11;11(1):2724–2734. doi: 10.1080/22221751.2022.2140608

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Serum NAb responses against SARS-CoV-2 VOCs and VOIs in UB-612 immunized rhesus macaques. (A) CPE NAb titers in group-pooled macaque sera against live viruses: D614G, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.v2) in 30 and 100 μg dose groups at 1 week after the 3^rd immunization. The numbers on top of each bar represent the NAb titer in group-pooled sera. (B) NAb titers against SARS-CoV-2 pseudoviruses expressing S protein from original Wuhan strain (WT), 3 VOCs: Alpha (B.1.1.7), Beta (B.1.351) and Gamma (P.1), and 2 VOIs: Epsilon (B.1.429) and Iota (B.1.526). Sera were collected at 2 or 6 weeks after the 2^nd immunization, and 1 week after the 3^rd immunization. Each bar represents GMT ± SD NAb titer, with GMT value above.