Table 3.
Pooled analysis of the association of MPP-CV and subsequent deterioration of renal function in different types of patients.
| Models for subsequent deterioration of renal function | Medical sepsis (n = 2506) |
Cardiac surgery (n = 8385) |
Others (n = 4422) |
|||
|---|---|---|---|---|---|---|
| Standard OR (95% CI) | p value | Standard OR (95% CI) | p value | Standard OR (95% CI) | p value | |
| MPP-CV | (per 4.68%) | (per 4.10%) | (per 5.31%) | |||
| Model 1 | 1.16 (1.06, 1.26) | <.001 | 1.09 (1.04, 1.14) | <.001 | 1.16 (1.08, 1.23) | <.001 |
| Model 2 | 1.16 (1.07, 1.26) | <.001 | 1.06 (1.01, 1.11) | .02 | 1.15 (1.08, 1.23) | <.001 |
| Model 3 | 1.13 (1.04, 1.23) | .004 | 1.05 (1.00, 1.10) | .03 | 1.12 (1.05, 1.20) | <.001 |
| Model 4 | 1.11 (1.01, 1.21) | .02 | 1.07 (1.02, 1.12) | .006 | 1.12 (1.05, 1.20) | <.001 |
| Model 5 | 1.11 (1.01, 1.21) | .02 | 1.04 (1.00, 1.10) | .08 | 1.10 (1.03, 1.18) | .007 |
Model 1: univariate analyses; model 2: model 1 plus adjusting age, gender, body mass index, ethnicity; model 3: model 2 plus adjusting surgery admission, cardiovascular ICU, history of hypertension, history of diabetes, history of chronic kidney disease, history of chronic heart failure, modified SOFA score and OASIS during the first 24 h; model 4: model 3 plus adjusting cumulative vasopressor dose during the first 24 h, sedatives use or not during the first 24 h, mechanical ventilation or not during the first 24 h, transfusion of RBCs during the first 24 h, AKI at the first 24 h, sepsis or not before the 24 h of ICU admission, exposure to ≥ 2 nephrotoxins before and after 24 h of ICU admission; model 5: additionally adjusting time-weighted average MPP based on model 4.