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. 2022 Nov 14:1–6. Online ahead of print. doi: 10.1038/s41390-022-02374-4

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© The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 3 — A neutralization antibody proxy assay determined the level of antibodies that block binding of the spike protein receptor-binding domain to the human host receptor angiotensin-converting enzyme 2 (ACE2). The assay threshold for positivity was 30% indicating the presence of neutralizing antibodies. RBD from the original 2019-nCoV or RBD from the SARS-CoV-2 Omicron variant were utilized. Plasma samples (n = 37) were obtained after 2-doses of the vaccine (Visit 1) and after the 3rd vaccine dose (Visit 2). The median percentage of surrogate neutralizing antibodies is displayed above the graph.