Yong 2005.

Study characteristics
Methods	RCT
Participants	89 newborn very low birth weight infants with respiratory distress treated with nasal CPAP via Infant Flow Driver (as primary support or postextubation)
Interventions	Mask (Infant Flow Driver): n = 41 Prongs (Infant Flow Driver): n = 48
Outcomes	Nasal trauma (crusting and excoriation, bleeding, narrowing of the nasal passage) Duration of CPAP use Duration of supplemental oxygen Duration of hospitalisation Bronchopulmonary dysplasia Death before discharge Treatment failure not reported – author contacted September 2021
Notes	Setting: Kuala Lumpur, Malaysia (2001–2003) Funding: research grant (FF/28/2001) from the Faculty of Medicine, Universiti Kebangsaan, Malaysia
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Sealed opaque envelopes "shuffled randomly".
Allocation concealment (selection bias)	Low risk	Sequentially numbered sealed opaque envelopes.
Blinding (performance bias and detection bias) All outcomes	High risk	Open label.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All participants randomised were analysed and reported.
Selective reporting (reporting bias)	Low risk	No access to protocol but unlikely.
Other bias	Low risk	No evidence imbalance in baseline demographics.

CPAP: continuous positive airway pressure; FiO₂: fraction of inspired oxygen; n: number of participants; RCT: randomised controlled trial; SpO₂: oxygen saturation.