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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Semin Liver Dis. 2022 Aug 24;42(3):233–249. doi: 10.1055/s-0042-1755316

Figure 2. The caspase-2–dependent activation of de novo lipogenesis.

Figure 2.

ER and IL-17A facilitate TNFα/TNFR-mediated lipogenesis in alcohol-damaged hepatocytes via activation of the caspase 2-SP1-SREBP1/2-DHCR7 pathway. Schematic representation of cholesterol and fatty acid synthesis pathways.