FIGURE 5.

Forest plot of Cox proportional hazards model of OS with individual predicted cemiplimab (a) C_trough and (b) C_av after the first dose and baseline covariates as model predictors in patients with R/M CC from EMPOWER‐Cervical 1/GOG‐3016/ENGOT‐cx9 (Cox proportional hazard modeling data shown for 293 out of 295 patients as baseline albumin values were not available for two patients). C_trough and C_av were fit based on after first dose values in this model. Continuous covariates were standardized to have a mean of 0 and SD of 1 by centering values from the mean value and scaling by the SD of the covariate. Interpretation of the estimated HR is based on a change in one unit of SD from the mean value rather than a change in one unit of the covariate from the baseline value of 0. The 95% CI represents the 95% CI of the HR estimate, where a value of 1 contained within the interval indicates that the covariate is not significant. Mean values are detailed in Table S8. C_av, average concentration; CI, confidence interval; C_trough, trough serum concentration; ECOG, Eastern Cooperative Oncology Group; ENGOT, European Network of Gynecological Oncological Trial; GOG, Gynecologic Oncology Group; HR, hazard ratio; OS, overall survival; R/M CC, recurrent or metastatic cervical cancer.