Table 1:
Demographic and clinical characteristics of the patients
| Case information | Total | Relapse-free cases | Relapsed cases | p Value |
|---|---|---|---|---|
| Number of cases | 24 | 13 | 11 | |
| Men/women | 15/9 | 8/5 | 7/4 | 0.9157 a |
| Age (y) | ||||
| Range | 19–65 | 19–65 | 19–44 | |
| Mean ± SD | 31.4 ± 13.9 | 34.2 ± 17.4 | 28.0 ± 7.7 | 0.9305 b |
| Median (IQR) | 27.5 (21.0–36.8) | 28.0 (19.5–52.5) | 27.0 (21.0–32.0) | |
| Disease duration (mo) | ||||
| Range | 1–60 | 1–60 | 1–39 | |
| Mean ± SD | 11.0 ± 14.8 | 10.3 ± 16.5 | 11.9 ± 13.3 | 0.5202 b |
| Median (IQR) | 5.0 (2.0–12.8) | 3.0 (2.0–12.0) | 8.0 (2.0–13.0) | |
| Location | 0.4083 a | |||
| L1 (ileal) | 1 | 1 | 0 | |
| L2 (colonic) | 8 | 5 | 3 | |
| L3 (ileocolonic) | 15 | 7 | 8 | |
| L4 (isolated upper lesions) | 0 | 0 | 0 | |
| Behavior | 0.4757 a | |||
| B1 (nonstricturing, nonpenetrating) | 17 | 10 | 7 | |
| B2 (stricturing) | 7 | 3 | 4 | |
| B3 (penetrating) | 0 | 0 | 0 | |
| Perianal disease modifier | 16 | 9 | 7 | |
| Anal fistula | 11 | 7 | 4 | |
| Anal skin tag | 8 | 4 | 4 | |
| Current smoker | 5 | 5 | 0 | 0.0071 a |
| Before induction treatment | ||||
| CDAI score | ||||
| Range | 52–834 | 52–566 | 95–834 | |
| Mean ± SD | 340 ± 218 | 242 ± 145 | 456 ± 239 | 0.0132 c |
| Median (IQR) | 265 (177–547) | 202 (146–293) | 346 (281–661) | |
| < 150 | 5 | 4 | 1 | |
| 150–220 (mild–moderate) | 4 | 3 | 1 | |
| 220–450 (moderate–severe) | 8 | 4 | 4 | |
| > 450 (severe/fulminant) | 7 | 2 | 5 | |
| CRP concentration (mg/dL) | ||||
| Mean ± SD | 5.3 ± 6.0 | 2.8 ± 3.8 | 8.1 ± 7.0 | 0.0127 b |
| Median (IQR) | 2.5 (0.8–7.1) | 1.0 (0.6–4.5) | 5.7 (2.2–12.8) | |
| After induction treatment (before follow-up studies) | ||||
| CDAI score | ||||
| Range | 2–98 | 2–98 | 28–90 | |
| Mean ± SD | 53 ± 26 | 46 ± 27 | 62 ± 23 | 0.1400 c |
| Median (IQR) | 53 (35–79) | 47 (31–61) | 64 (39–84) | |
| CRP concentration (mg/dL) | ||||
| Mean ± SD | 0.13 ± 0.20 | 0.09 ± 0.15 | 0.19 ± 0.24 | 0.1012 b |
| Median (IQR) | 0.1 (0–0.10) | 0 (0–0.10) | 0.10 (0.04–0.30) | |
| Mucosal healing | 10 | 4 | 6 | 0.2376 a |
| Follow-up period (d) | ||||
| Range | 163–5475 | 523–5320 | 163–5475 | |
| Mean ± SD | 2996 ± 1525 | 3096 ± 1589 | 2878 ± 1514 | 0.7362 c |
| Median (IQR) | 3121 (1676–4221) | 3201 (1697–4636) | 3041 (1675–4023) |
Comparison between relapse-free cases and relapsed cases through either χ2 test, Wilcoxon rank sum test, or Student t-test.
a
χ2 test.
b
Wilcoxon rank sum test.
c
Student t-test.
CDAI, Crohn’s disease activity index;CRP, C-reactive protein; IQR, interquartile range; SD, standard deviation.