Table 3:

Literature review of relapse-free rate and surgical rate in adult patients with Crohn’s disease

Reference	Country	Study participants and Y(s)	Number of cases	Cumulative relapse-free rate (y [%])		Cumulative surgical rate (y [%])
				5	10	5	10
Munkholm et al 5	Denmark	PBIC 1962–1987	373	22	12	n.d.	n.d.
Wolters et al 6	European countries, Israel	PBIC 1991–1993	358	31	23	21	29
Solberg et al 7	Norway	PBIC 1990–1994	237	15	10	27	38
Nguyen et al 36	Canada	2001–2008	1119			18	n.a.
Frolkis et al 37	Meta-analysis	1990–	3,239, a 3,253 b			28	39
		2000–	1193			24	n.a.
Rungoe et al 38	Denmark	1995–2002	3718			27	31
		2003–2011	5552			20	23
Niewiadomski et al 39	Australia	PBIC 2007–2013	146			26	n.a.
Kim et al 40	Korea	PBIC 2006–2012	11,267			9	n.a.
Okada et al 41	Japan	1973–1988	58			29	46
Present study	Japan	2003–2017	26	52	52	12	19

^a Case number for surgical rate at 5 y.

^b Case number for surgical rate at 10 y.

n.a., not available; n.d., not described; PBIC, population-based inception cohort.