. Author manuscript; available in PMC: 2023 Nov 23.

Published in final edited form as: J Am Chem Soc. 2022 Nov 10;144(46):21035–21045. doi: 10.1021/jacs.2c04626

Table 2.

Pharmacokinetic parameters of SM141 and SM142.

Parameters		SM141		SM142
Parameters	IV	PO	IP	IV	PO
T_1/2 (h)	0.8	ND	0.8	2.1	2.1
T_max (h)	0.08	0.8	0.14	0.08	0.08
C_max (μM)	3.9	0.2	2.7	0.4	0.6
AUC_last (μM.h)	1.3	0.14	1.6	0.4	0.5
AUC_{INF_obs} (min.ng/mL)	42350	7325	49620	18490	20843
CI_Obs (mL/min/kg)	71.5		-	169	-
MRT_{INF_obs} (h)	0.4		-	1.9	-
V_{SS_obs} (l/kg)	1.6		-	13.2	-
% Bioavailability	-	5	35.2	-	37.5

IV: Intravenous dosing; IP: Intraperitoneal dosing; PO: Oral dosing. For SM141 the final formulation was 5/95 DMSO/saline and for SM142 the final formulation was 5% DMSO, 5% Tween-80, 90% saline (v:v:v).