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. 2022 Oct 31;13:1045395. doi: 10.3389/fgene.2022.1045395

FIGURE 2.

FIGURE 2

Identification of the hub gene. (A) The co-expressive differentially expressed genes in differently mRNA expression profiles (from GSE593, GSE31699, and GSE45189 datasets) and genome-wide DNA methylation genes (from GSE31699, GSE45189 datasets) by Venn diagram. M-GSE31699, M-GSE45189 indicated the differential DNA methylation genes. (B–D) The relative mRNA expression of TM4SF1, TNFSF10, and PLP1 by RT-qPCR. n = 14/groups. *** p < 0.001. ns no statistical significance.