Table 3. Correlations of hepatic expression of GHR/STAT5/IGF-1 signaling pathway with different clinico-biochemical parameters, Snail-1 and TGFBR2 in cirrhotic patients.

Variable	GHR protein expression		STAT5 protein expression		IGF-1 protein expression
	R	p-value	r	p-value	r	p-value
STAT5 hepatic expression	0.35	0.001 †	-------	--------	-------	-------
IGF-1 hepatic expression	0.45	0.02 †	0.53	0.0001†	-----	-----
Age (years)	- 0.30	0.03 †	-0.15	0.24†	-0.31	0.035 †
BMI (kg/m2)	0.20	0.12†	0.11	0.41†	0.33	0.011 †
Smoking (Yes/No)	-0.09	0.47††	-0.05	0.72††	-0.08	0.53††
Platelets (1×103/μl)	0.01	0.96†	-0.10	0.44†	0.09	0.50†
Total bilirubin (mg/dL)	-0.07	0.61†	-0.09	0.47†	0.07	0.59†
ALT (IU/L)	-0.05	0.78†	-0.05	0.72†	-0.28	0.03 †
AST (IU/L)	-0.22	0.36†	-0.09	0.49†	-0.34	0.008 †
Serum albumin (gm/dl)	0.17	0.20†	0.14	0.29†	0.14	0.30†
Prothrombin time (seconds)	-0.22	0.09†	-0.07	0.59†	-0.27	0.036 †
INR	-0.12	0.38†	-0.14	0.28†	-0.18	0.231†
Serum creatinine (mg/dl)	-0.06	0.63†	-0.02	0.89†	-0.38	0.013 †
Alpha-fetoprotein (ng/ml)	-0.31	0.029 †	-0.29	0.04 †	-0.23	0.08†
Child-Pugh score	-0.06	0.70†	-0.21	0.06†	-0.02	0.92†
MELD score	-0.05	0.75†	-0.15	0.36†	-0.03	0.88†
Snail-1	-0.55	0.02†	-0.47	0.035 †	-0.51	0.009 †
TGFBR2 protein	0.47	0.034 †	0.49	0.023 †	0.57	<0.001 †

GHR: growth hormone receptor; STAT5: signal transducer and activator of transcription 5; IGF-1: insulin like growth factor-1; r: correlation coefficient; BMI: body mass index; kg/m²: kilogram/meter²; ALT: alanine aminotransferase; AST: aspartate transaminase; INR: international normalized ratio; MELD: model of end stage liver disease; TGFBR2: type2 transforming growth factor-beta receptor

†: Pearson’s correlation

††: Spearman’s correlation

Bold values denote significant results