Comparison 12. Single medication compared with alternate single medication ‐ non‐serious adverse events ‐ central nervous system.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
12.1 Sedation	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	3.50 [1.23, 9.92]
12.1.1 Olanzapine versus fluoxetine	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	3.50 [1.23, 9.92]
12.2 Restlessness	2	110	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.36, 2.32]
12.2.1 Loxapine versus chlorpromazine	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	1.50 [0.26, 8.50]
12.2.2 Olanzapine versus fluoxetine	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.23, 2.11]
12.3 Restlessness/anxiety	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 3.82]
12.3.1 Olanzapine versus asenapine	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 3.82]
12.4 Sleepiness/drowsiness	2	131	Risk Ratio (M‐H, Fixed, 95% CI)	1.35 [0.47, 3.88]
12.4.1 Olanzapine versus asenapine	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	6.74 [0.37, 124.21]
12.4.2 Loxapine versus chlorpromazine	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.80 [0.23, 2.76]
12.5 Fainting spells	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.68]
12.5.1 Loxapine versus chlorpromazine	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.68]
12.6 Akhatisia	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 3.82]
12.6.1 Olanzapine versus asenapine	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.19 [0.01, 3.82]
12.7 Moderate anxiety	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.53]
12.7.1 Olanzapine versus asenapine	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	0.32 [0.01, 7.53]
12.8 Fatigue	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	4.81 [0.24, 95.58]
12.8.1 Olanzapine versus asenapine	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	4.81 [0.24, 95.58]