Table 3.
Overview of the associations between blood cytokine levels and patient characteristics.
| sCD40L | CCL5 | VEGF | G-CSF | NLR | IL-17F | IP-10 | TNF-RI | IFN-γ | Granzyme A | TNF | IL-12p70 | IL-2 | IL-4 | IL-1β | ICAM- 1 | Angiogenin | IL-6 | IL-5 | IL-10 | IL-8 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-8 | r=-0.052 p=0.284 |
r=0.092 p=0.059 |
r=0.165 p=0.001 |
r=-0.016 p=0.737 |
r=0.086 p=0.08 |
r=0.009 p=0.857 |
r=0.203 p=3E-05 |
r=0.296 p=6E-10 |
r=0.141 p=0.009 |
r=0.23 p=2E-06 |
r=0.129 p=0.017 |
r=0.189 p=4x10-4 |
r=0.257 p=1x10-6 |
r=0.237 p=9x10-6 |
r=0.270 p=4x10-7 |
r=0.337 p=10-12 |
r=0.359 p=2x10-14 |
r=0.617 p=10-45 |
r=0.444 p=5x10-18 |
r=0.6 p=5x10-35 |
|
| IL-10 | r=-0.025 p=0.648 |
r=0.045 p=0.401 |
r=0.13 p=0.016 |
r=0.197 p=2E-04 |
r=0.171 p=0.002 |
r=0.022 p=0.688 |
r=0.121 p=0.025 |
r=0.246 p=4x10-6 |
r=0.176 p=0.001 |
r=0.237 p=9x10-6 |
r=0.211 p=8x10-5 |
r=0.291 p=4x10-8 |
r=0.31 p=4x10-9 |
r=0.354 p=10-11 |
r=0.386 p=1x10-13 |
r=0.395 p=3x10-14 |
r=0.393 p=4x10-14 |
r=0.456 p=4x10-19 |
r=0.587 p=3x10-33 |
||
| IL-5 | r=-0.069 p=0.203 |
r=-0.142 p=0.009 |
r=0.084 p=0.119 |
r=0.099 p=0.066 |
r=0.034 p=0.534 |
r=0.121 p=0.024 |
r=0.092 p=0.09 |
r=0.04 p=0.461 |
r=0.223 p=3x10-5 |
r=0.324 p=8x10-10 |
r=0.189 p=4x10-4 |
r=0.453 p=9x10-19 |
r=0.277 p=2x10-7 |
r=0.306 p=7x10-9 |
r=0.395 p=3x10-14 |
r=0.263 p=8x10-7 |
r=0.408 p=3x10-15 |
r=0.354 p=10-11 |
|||
| IL-6 | r=0.008 p=0.863 |
r=-0.026 p=0.601 |
r=0.145 p=0.003 |
r=-0.092 p=0.058 |
r=0.065 p=0.185 |
r=0.049 p=0.317 |
r=0.313 p=4x10-11 |
r=0.279 p=5x10-9 |
r=0.168 p=0.002 |
r=0.239 p=6x10-7 |
r=0.16 p=0.003 |
r=0.198 p=2x10-4 |
r=0.272 p=3x10-7 |
r==0.231 p=2x10-5 |
r=0.230 p=2x10-5 |
r=0.108 p=0.026 |
r=0.268 p=2x10-8 |
||||
| Angiogenin | r=0.129 p=0.008 |
r=0.023 p=0.635 |
r=0.199 p=4E-05 |
r=0.165 p=0.001 |
r=-0.004 p=0.932 |
r=0.158 p=0.001 |
r=0.092 p=0.058 |
r=0.161 p=0.001 |
r=0.108 p=0.045 |
r=0.262 p=5x10-8 |
r=0.002 p=0.966 |
r=0.066 p=0.22 |
r=0.178 p=0.001 |
r=0.122 p=0.024 |
r=0.158 p=0.003 |
r=0.396 p=3x10-17 |
|||||
| ICAM- 1 | r=-0.017 p=0.731 |
r=0.119 p=0.014 |
r=0.113 p=0.02 |
r=0.091 p=0.061 |
r=0.122 p=0.013 |
r=0.073 p=0.133 |
r=0.001 p=0.976 |
r=0.313 p=5x10-11 |
r=0.044 p=0.412 |
r=0.09 p=0.065 |
r=-0.082 p=0.131 |
r=-0.04 p=0.463 |
r=0.157 p=0.003 |
r=0.114 p=0.035 |
r=0.089 p=0.099 |
||||||
| IL-1β | r=-0.014 p=0.802 |
r=-0.091 p=0.094 |
r=0.077 p=0.157 |
r=0.19 p=4E-04 |
r=0.108 p=0.048 |
r=0.159 p=0.003 |
r=-0.056 p=0.3 |
r=-0.022 p=0.691 |
r=0.190 p=4x10-4 |
r=0.192 p=3x10-4 |
r=0.357 p=9x10-12 |
r=0.405 p=5x10-15 |
r=0.487 p=7x10-22 |
r=0.507 p=7x10-24 |
|||||||
| IL-4 | r=-0.013 p=0.815 |
r=-0.06 p=0.271 |
r=-0.009 p=0.869 |
r=0.013 p=0.817 |
r=0.116 p=0.035 |
r=0.104 p=0.055 |
r=-0.024 p=0.655 |
r=-0.006 p=0.907 |
r=0.19 p=4x10-4 |
r=0.043 p=0.426 |
r=0.386 p=1x10-13 |
r=0.289 p=5x10-8 |
r=0.484 p=10-21 |
||||||||
| IL-2 | r=0.007 p=0.89 |
r=-0.074 p=0.169 |
r=-0.007 p=0.892 |
r=0.03 p=0.573 |
r=0.008 p=0.891 |
r=0.049 p=0.362 |
r=0.095 p=0.077 |
r=-0.085 p=0.114 |
r=0.317 p=2x10-9 |
r=0.142 p=0.008 |
r=0.407 p=4x10-15 |
r=0.245 p=4x10-6 |
|||||||||
| IL-12p70 | r=-0.071 p=0.191 |
r=-0.114 p=0.034 |
r=0.062 p=0.255 |
r=0.052 p=0.336 |
r=-0.039 p=0.473 |
r=0.12 p=0.027 |
r=-0.026 p=0.637 |
r=-0.084 p=0.122 |
r=0.22 p=4x10-5 |
r=0.184 p=0.001 |
r=0.373 p=8E-13 |
||||||||||
| TNF | r=0.006 p=0.915 |
r=-0.041 p=0.452 |
r=0.015 p=0.78 |
r=-0.048 p=0.37 |
r=0.011 p=0.836 |
r=-0.013 p=0.805 |
r=-0.062 p=0.254 |
r=-0.095 p=0.079 |
r=0.173 p=0.001 |
r=0.036 p=0.506 |
|||||||||||
| Granzyme A | r=0.057 p=0.242 |
r=0.0002 p=0.996 |
r=0.285 p=2E-09 |
r=0.191 p=8E-05 |
r=-0.089 p=0.07 |
r=0.143 p=0.003 |
r=0.313 p=4x10-11 |
r=0.107 p=0.029 |
r=0.132 p=0.014 |
||||||||||||
| IFN-γ | r=-0.04 p=0.462 |
r=-0.11 p=0.041 |
r=0.003 p=0.958 |
r=0.03 p=0.585 |
r=0.023 p=0.678 |
r=0.289 p=5x10-8 |
r=0.093 p=0.086 |
r=-0.001 p=0.985 |
|||||||||||||
| TNF-RI | r=0.14 p=0.004 |
r=0.178 p=2x10-4 |
r=0.226 p=3x10-6 |
r=0.114 p=0.02 |
r=0.222 p=5x10-6 |
r=0.068 p=0.164 |
r=0.183 p=2x10-4 |
||||||||||||||
| IP-10 | r=0.049 p=0.315 |
r=-0.021 p=0.671 |
r=0.039 p=0.428 |
r=-0.192 p=7x10-5 |
r=-0.183 p=2x10-4 |
r=0.067 p=0.171 |
|||||||||||||||
| IL-17F | r=-0.03 p=0.538 |
r=-0.134 p=0.006 |
r=0.104 p=0.032 |
r=0.037 p=0.45 |
r=-0.015 p=0.754 |
||||||||||||||||
| NLR | r=0.025 p=0.618 |
r=0.077 p=0.116 |
r=0.123 p=0.012 |
r=0.259 p=9x10-8 |
|||||||||||||||||
| G-CSF | r=0.163 p=0.001 |
r=0.088 p=0.071 |
r=0.254 p=10-7 |
||||||||||||||||||
| VEGF | r=0.352 p=9x10-14 |
r=0.352 p=8x10-14 |
|||||||||||||||||||
| CCL5 | r=0.37 p=4E-15 |
Weak, but significant correlations (|r|<0.3) were highlighted in light green, while stronger correlations were highlighted in deeper green. Markers with multiple (>1) stronger correlations with each other have been highlighted in light blue. Results with p<0.05, but FDR >0.1 are highlighted in grey.
IL, interleukin; IFN-γ, interferon gamma; TNF, tumour necrosis factor; ICAM-1, intercellular adhesion molecule 1; IP-10, interferon-gamma induced protein 10; VEGF, vascular endothelial growth factor; angiogenin, sCD40L, soluble CD40 ligand; G-CSF, granulocyte-colony stimulating factor; CCL5, CC motif chemokine ligand 5; TNF-RI, soluble TNF-receptor I.