TABLE 3.
Cytokine profiles in mice
| Time point and exptl group | Concn (pg/ml) of cytokinea
|
||||
|---|---|---|---|---|---|
| IFN-γ | TNF-α | IL-12 | IL-10 | TGF-β1 | |
| 2 wk | |||||
| C57BL/6J | 35 ± 10 | 56.4 ± 4.2 | 166 ± 2.2 | 150 ± 0.4 | 8.5 ± 0.8 |
| β2−/− | 46 ± 7 (P = 0.300)b | 65.9 ± 4.4 (P = 0.828) | 209 ± 27 (P = 0.248) | 266 ± 90 (P = 0.326) | 10.0 ± 0.4 (P = 0.239) |
| 4 wk | |||||
| C57BL/6J | 45 ± 0.2 | 63.1 ± 5.5 | 84 ± 42 | 131 ± 21 | 10.9 ± 2.2 |
| β2−/− | 39 ± 1.5 (P = 0.426) | 82.4 ± 4.8 (P = 0.115) | 82.2 ± 39 (P = 0.156) | 179 ± 13 (P = 0.188) | 11.4 ± 0.9 (P = 0.853) |
| 6 wk | |||||
| C57BL/6J | 27 ± 2 | 40 ± 9 | 109 ± 19 | 428 ± 61 | 169 ± 18 |
| β2−/− | 25 ± 3 (P = 0.270) | 44 ± 3 (P = 0.351) | 106 ± 23 (P = 0.410) | 258 ± 37 (P < 0.05) | 159 ± 26 (P = 0.0240) |
| 8 wk | |||||
| C57BL/6J | 51 ± 7 | 30 ± 9 | 75 ± 16 | 121 ± 20 | 181 ± 27 |
| β2−/− | 35 ± 5 (P < 0.05) | 66 ± 8 (P < 0.05) | 84 ± 8 (P = 0.235) | 118 ± 9 (P = 0.634) | 159 ± 31 (P = 182) |
a
Cytokines were measured in the supernatants of splenic cells 24 h after being cultured in vitro.
b
P values are for comparisons between mouse strains.