Table 4. European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) clinical domains and criteria for systemic lupus erythematosus.
Antinuclear antibodies (ANA) must be present at a titer of ≥1:80 on HPe-2 cells, or an equivalent positive test is required. The additive criteria follow a positive ANA; the presence of at least one clinical criterion and a total score of 10 is required for classification as SLE. Within each domain, only the highest weighted criterion is counted toward the score.
| Clinical Domains and Criteria | Criteria | Weight |
| Constitutional | Fever | 2 |
| Hematologic | Leukopenia | 3 |
| Thrombocytopenia | 4 | |
| Autoimmune hemolysis | 4 | |
| Neuropsychiatric | Delirium | 2 |
| Psychosis | 3 | |
| Seizure | 5 | |
| Mucocutaneous | Non-scarring alopecia | 2 |
| Oral ulcers | 2 | |
| Subacute cutaneous or discoid lupus | 4 | |
| Acute cutaneous lupus | 6 | |
| Serosal | Pleural or pericardial effusion | 5 |
| Acute pericarditis | 6 | |
| Musculoskeletal | Joint involvement | 6 |
| Renal | Proteinuria >0.5g/24h | 4 |
| Renal biopsy class II or V lupus nephritis | 8 | |
| Renal biopsy class III or IV lupus nephritis | 10 |