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. 2021 Aug 6;81(20):5268–5283. doi: 10.1158/0008-5472.CAN-21-0494

Figure 2.

Figure 2. WTAPP1 promotes malignant phenotypes of PDAC in vitro and in vivo. A–C, Effects of WTAPP1 overexpression or knockdown on PDAC-cell proliferation (A), colony formation (B), and migration or invasion (C). Data are mean ± SEM from at least three independent experiments. D, Effects of WTAPP1 expression change on subcutaneous PDAC xenograft growth in mice. Images of xenograft tumors (left) and tumor growth curves over time (right). Data represent mean ± SEM (N = 5). E and F, Effects of WTAPP1 expression change on the growth of PDAC xenograft transplanted in mouse pancreas. Luminescence images (E) and quantification (F) of radiance intensity. Data represent mean ± SEM. G, Effect of WTAPP1 expression change on survival time of mice with PDAC xenograft in the pancreas (N = 8). H, Percentage of mice with or without metastasis in each group (N = 8). All statistical examinations in this figure are Student t tests unless specified. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

WTAPP1 promotes malignant phenotypes of PDAC in vitro and in vivo. A–C, Effects of WTAPP1 overexpression or knockdown on PDAC-cell proliferation (A), colony formation (B), and migration or invasion (C). Data are mean ± SEM from at least three independent experiments. D, Effects of WTAPP1 expression change on subcutaneous PDAC xenograft growth in mice. Images of xenograft tumors (left) and tumor growth curves over time (right). Data represent mean ± SEM (N = 5). E and F, Effects of WTAPP1 expression change on the growth of PDAC xenograft transplanted in mouse pancreas. Luminescence images (E) and quantification (F) of radiance intensity. Data represent mean ± SEM. G, Effect of WTAPP1 expression change on survival time of mice with PDAC xenograft in the pancreas (N = 8). H, Percentage of mice with or without metastasis in each group (N = 8). All statistical examinations in this figure are Student t tests unless specified. *, P < 0.05; **, P < 0.01; ***, P < 0.001.