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. 2021 Aug 17;30(11):2001–2009. doi: 10.1158/1055-9965.EPI-21-0423

Table 2.

Number and location of joinpoints in the final model and trend measures: annual absolute change in 5-year and 1-year AAC_S(5) and AAC_S(1), respectively, and percent change in the annual probability of cancer death (APC_D) with respective 95% confidence intervals.

Cancer site Stage No. JPs final model No. alive Start year End year AAC_S(5) AAC_S(5) 95% C.I. AAC_S(1) AAC_S(1) 95% C.I. APC_D APC_D 95% C.I.
Breast Local 2 4,163 1975 1982 −0.05 pp (−0.226 to 0.126) n.s. 0.00 pp (−0.005 to 0.003) n.s. 0.6% (−1.485 to 2.662) n.s.
1982 1988 0.81 pp (0.669–0.951) 0.02 pp (0.001–0.031) 12.3% (−14.184 to −10.371)
1988 2015 0.13 pp (0.116–0.151) 0.00 pp (0.000–0.005) 6.7% (−7.652 to −5.782)
Breast Regional 3 3,363 1975 1979 0.07 pp (−0.285 to 0.424) n.s. 0.01 pp (−0.042 to 0.062) n.s. −0.3% (−1.594 to 1.069) n.s.
1979 1996 0.72 pp (0.666–0.773) 0.10 pp (0.089–0.106) −3.2% (−3.462 to −2.965)
1996 2000 1.23 pp (1.047–1.416) 0.15 pp (0.128–0.174) 7.5% (−8.580 to −6.396)
2000 2015 0.31 pp (0.247–0.365) 0.04 pp (0.029–0.043) −2.6% (−3.051 to −2.050)
Breast Distant 1 676 1975 1993 0.30 pp (0.212–0.391) 0.28 pp (0.197–0.370) −0.9% (−1.234 to −0.665)
1993 2015 0.79 pp (0.711–0.865) 0.54 pp (0.486–0.592) −2.2% (−2.391 to −1.962)
Melanoma Local 1 941 1975 1981 0.02 pp (−0.307 to 0.354) n.s. 0.00 pp (−0.002 to 0.002) n.s. −0.3% (−4.083 to 3.538) n.s.
1981 2015 0.25 pp (0.223–0.277) 0.00 pp (−0.004 to 0.008) n.s. 8.7% (−9.715 to −7.760)
Melanoma Regional 0 134 1975 2015 0.47 pp (0.380–0.559) 0.12 pp (0.096–0.147) −1.6% (−1.884 to −1.292)
Melanoma Distant 1 60 1975 2009 0.14 pp (0.046–0.237) 0.18 pp (0.056–0.297) −0.5% (−0.808 to −0.153)
2009 2015 2.86 pp (2.096–3.629) 2.81 pp (2.103–3.517) 7.9% (−9.876 to −5.885)
CML All 2 294 1975 1995 0.67 pp (0.453–0.879) 0.50 pp (0.338–0.671) −1.9% (−2.464 to −1.266)
1995 2010 2.48 pp (2.208–2.743) 1.23 pp (1.079–1.371) 7.5% (−8.357 to −6.578)
2010 2015 −1.05 pp (−2.479 to 0.375) n.s. −0.42 pp (−1.009 to 0.160) n.s. 4.2% (−1.428 to 9.897) n.s.
NHL All 4 1,731 1975 1983 0.82 pp (0.455–1.177) 0.61 pp (0.339–0.873) −2.3% (−3.311 to −1.322)
1983 1990 −0.30 pp (−0.625 to 0.017) n.s. −0.22 pp (−0.454 to 0.011) n.s. 0.9% (−0.051 to 1.841) n.s.
1990 1995 0.76 pp (0.356–1.165) 0.55 pp (0.257–0.841) −2.2% (−3.387 to −1.055)
1995 2003 2.00 pp (1.785–2.216) 1.33 pp (1.188–1.481) 6.6% (−7.327 to −5.949)
2003 2015 0.40 pp (0.266–0.542) 0.25 pp (0.165–0.336) −1.7% (−2.324 to −1.137)

Note: Arrows up represent increasing survival; arrows down represent decreasing survival trends and n.s. are not statistically significant trends either increasing or decreasing. Bold numbers represent AAC_S(5) and AAC_S(1) > 1 survival percentage point (pp) for a later year of diagnosis, and APC_D<−5%.