Table 3.
TRAEs, occurring in e10%.
| Event | Any grade, n (%) | eGrade 3, n (%) |
|---|---|---|
| Hypothyroidism | 23 (76.67) | — |
| Hypertriglyceridemia | 19 (63.33) | 3 (10.00) |
| Hypercholesterolemia | 18 (60.00) | — |
| Elevated blood lactate dehydrogenase | 16 (53.33) | — |
| Elevated alanine aminotransferase | 15 (50.00) | 1 (3.33) |
| Hand-foot syndrome | 15 (50.00) | — |
| Elevatedγ glutamyltransferase | 13 (43.33) | 2 (6.67) |
| Elevated aspartate aminotransferase | 13 (43.33) | — |
| Increased blood bilirubin | 13 (43.33) | — |
| Hyperuricemia | 12 (40.00) | — |
| Hypertension | 9 (30.00) | 1 (3.33) |
| Decreased white blood cell count | 8 (26.67) | — |
| Urinary tract infection | 8 (26.67) | — |
| Decreased neutrophil count | 8 (26.67) | — |
| Proteinuria | 8 (26.67) | — |
| Diarrhea | 8 (26.67) | — |
| Hyperthyroidism | 7 (23.33) | — |
| Elevated alkaline phosphatase | 6 (20.00) | 1 (3.33) |
| Increased creatine phosphokinase | 5 (16.67) | 1 (3.33) |
| Occult blood | 5 (16.67) | — |
| Elevated thyroid-stimulating hormone | 4 (13.33) | — |
| Weight loss | 4 (13.33) | — |
| ECG T-wave abnormality | 4 (13.33) | — |
| Increased lipase | 4 (13.33) | — |
| Sinus tachycardia | 4 (13.33) | — |
| Laryngeal hemorrhage | 3 (10.00) | — |
| Anemia | 3 (10.00) | 1 (3.33) |
| Arrhythmia | 3 (10.00) | — |
| Swollen gums | 3 (10.00) | — |
| Sinus bradycardia | 3 (10.00) | — |