Table 2.
Baseline patient and disease characteristics by baseline EGFR-activating mutation subgroup and by treatment arms.
| Total | Ex19del | Ex21L858R | |||||
|---|---|---|---|---|---|---|---|
| Ex19del (N = 243) | Ex21L858R (N = 204) | RAM+ERL (N = 123) | PBO+ERL (N = 120) | RAM+ERL (N = 99) | PBO+ERL (N = 105) | ||
| Sex, n (%) | Female | 146 (60) | 136 (67) | 74 (60) | 72 (60) | 66 (67) | 70 (67) |
| Age in years, median (range) | 63 (23–84) | 66 (41–89) | 64 (27–84) | 63 (23–83) | 67 (44–86) | 66 (41–89) | |
| Racea | Asian | 174 (72) | 170 (83) | 89 (72) | 85 (71) | 81 (82) | 89 (85) |
| Caucasian | 67 (28) | 33 (16) | 34 (28) | 33 (28) | 18 (18) | 15 (14) | |
| Smoking history, n (%) | Never | 144 (59) | 127 (62) | 71 (58) | 73 (61) | 61 (62) | 66 (63) |
| ECOG performance status, n (%) | 0 | 131 (54) | 103 (51) | 65 (53) | 66 (55) | 50 (51) | 53 (51) |
| Disease classification, n (%) | Primary metastatic | 207 (85) | 178 (87) | 103 (84) | 104 (87) | 91 (92) | 87 (83) |
| Recurrent metastatic | 36 (15) | 26 (13) | 20 (16) | 16 (13) | 8 (8) | 18 (17) | |
| Metastases sites, n (%) | Lung | 224 (92) | 188 (92) | 112 (91) | 112 (93) | 93 (94) | 95 (91) |
| Lymph | 152 (63) | 127 (62) | 78 (63) | 74 (62) | 64 (65) | 63 (60) | |
| Bone | 63 (26) | 69 (34) | 35 (29) | 28 (23) | 33 (33) | 36 (34) | |
| Liver | 26 (11) | 19 (9) | 11 (9) | 15 (13) | 10 (10) | 9 (9) | |
| Other | 146 (60) | 104 (51) | 70 (57) | 76 (63) | 48 (49) | 56 (53) | |
| Number of metastatic sites | 1 | 29 (12) | 23 (11) | 12 (10) | 17 (14) | 9 (9) | 14 (13) |
| 2 | 90 (37) | 86 (42) | 50 (41) | 40 (33) | 46 (47) | 40 (38) | |
| 3 | 99 (41) | 74 (36) | 50 (41) | 49 (41) | 32 (32) | 42 (40) | |
| 4 | 20 (8) | 15 (7) | 11 (9) | 9 (8) | 9 (9) | 6 (6) | |
| ≥5 | 5 (2) | 6 (3) | 0 | 5 (4) | 3 (3) | 3 (3) | |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; n, number of patients per category; N, number of patients in population.
aPBO + ERL arm included three Other: one Black or African American, one Missing (ex19del group), one American Indian or Alaska Native (ex21L858R group).