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. 2022 Jun 13;28(16):3452–3463. doi: 10.1158/1078-0432.CCR-21-4020

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 2. Immune activation in a subset of tumors consistent with effector T-cell co-stimulation. A, An increase in CD8 infiltrate following MOXR0916 treatment was observed. B, An increase in effector T-cell activation signature, comprised of CD8, EOMES, granzyme A&B, IFN gamma, and perforin, was observed. C, Increase in PD-L1 expression, as measured by IHC, is presumably reflective of adaptive upregulation downstream of IFNγ signaling. — Immune activation in a subset of tumors consistent with effector T-cell costimulation. A, An increase in CD8 infiltrate following MOXR0916 treatment was observed. B, An increase in effector T-cell activation signature, comprised of CD8, EOMES, granzyme A&B, IFN gamma, and perforin, was observed. C, Increase in PD-L1 expression, as measured by IHC, is presumably reflective of adaptive upregulation downstream of IFNγ signaling.