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. 2022 Jun 13;28(16):3452–3463. doi: 10.1158/1078-0432.CCR-21-4020

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 3. Patient with renal cell carcinoma (RCC) with serial biopsies (pre- and post-treatment) of a liver metastasis that illustrated pharmacodynamic observations consistent with the hypothesized mechanism of action of MOXR0916. Biopsies were stained for the expression of (A) PD-L1 and (B) CD3+/FoxP3+ Treg cells, and assayed for (C) post-treatment tumor gene expression. — Patient with renal cell carcinoma (RCC) with serial biopsies (pre- and post-treatment) of a liver metastasis that illustrated pharmacodynamic observations consistent with the hypothesized mechanism of action of MOXR0916. Biopsies were stained for the expression of (A) PD-L1 and (B) CD3⁺/FoxP3⁺ T_reg cells, and assayed for (C) post-treatment tumor gene expression.