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. 2021 Jul 2;81(16):4205–4217. doi: 10.1158/0008-5472.CAN-21-0086

Figure 4.

Figure 4. The E-genes and I-genes influence the mutational propensities. A, The Upset plot shows the overlap between the E-genes, I-genes, COSMIC CGCs, and another three published benchmark cancer gene sets. B, The E-genes and I-genes are enriched for determinants of different MPs at the pan-cancer level based on the background of 2,314 candidate genes. The dot color represents the −log10 (FDR). The dot size represents the OR of enrichment based on the background of 2,314 candidate genes. C, The pathways enriched in E-genes and I-genes. The dot color represents the −log10 (FDR). The dot size represents the OR of enrichment. D, The I-genes impact on the MPs through different immune cell activities in TIME.

The E-genes and I-genes influence the mutational propensities. A, The Upset plot shows the overlap between the E-genes, I-genes, COSMIC CGCs, and another three published benchmark cancer gene sets. B, The E-genes and I-genes are enriched for determinants of different MPs at the pan-cancer level based on the background of 2,314 candidate genes. The dot color represents the −log10 (FDR). The dot size represents the OR of enrichment based on the background of 2,314 candidate genes. C, The pathways enriched in E-genes and I-genes. The dot color represents the −log10 (FDR). The dot size represents the OR of enrichment. D, The I-genes impact on the MPs through different immune cell activities in TIME.