Table 3.
OS and PFS per AFP cutoffs and HCC etiology.
| OS | PFS per IRF-assessed RECIST 1.1 | |||||
|---|---|---|---|---|---|---|
| HR (95% CI); Pa | HR (95% CI); Pa | |||||
| Etiology | n | ≥75% AFP decrease | ≤10% AFP increase | n | ≥75% AFP decrease | ≤10% AFP increase |
| HBV | 80 | 0.22 (0.07–0.68) | 0.38 (0.21–0.69) | 61 | 0.46 (0.22–0.95) | 0.38 (0.18–0.81) |
| P = 0.008 | P = 0.002 | P = 0.037 | P = 0.012 | |||
| HCV | 34 | 0.56 (0.19–1.63) | 0.34 (0.10–1.15) | 29 | 0.44 (0.15–1.30) | 0.29 (0.09–0.91) |
| P = 0.288 | P = 0.083 | P = 0.139 | P = 0.034 | |||
| Nonviral | 35 | 0.45 (0.14–1.43) | 0.74 (0.33–1.66) | 30 | 0.49 (0.15–1.64) | 0.52 (0.21–1.31) |
| P = 0.174 | P = 0.471 | P = 0.248 | P = 0.164 | |||
Abbreviations: AFP, alpha-fetoprotein; IRF, independent review facility; OS, overall survival; PFS, progression-free survival; RECIST 1.1, Response Evaluation Criteria in Solid Tumors version 1.1.
aEstimated using a Cox proportional hazards model adjusted for baseline AFP and age.