Table 3.
CBR in BCL2-high, BCL2-low, PIK3CA-wild-type, and PIK3CA-mutant subgroups.
BCL2-high | BCL2-low | PIK3CA-wild-type | PIK3CA-mutant | |||||
---|---|---|---|---|---|---|---|---|
Venetoclax plus fulvestrant | Fulvestrant | Venetoclax plus fulvestrant | Fulvestrant | Venetoclax plus fulvestrant | Fulvestrant | Venetoclax plus fulvestrant | Fulvestrant | |
n = 33 | n = 33 | n = 18 | n = 18 | n = 29 | n = 31 | n = 19 | n = 14 | |
CBR, n (%) | 6 (18.2) | 6 (18.2) | 0 | 1 (5.6) | 6 (20.7) | 3 (9.7) | 0 | 2 (14.3) |
Risk difference (%) | 0 | –5.56 | 11.01 | –14.29 | ||||
95% CI | –21.64 to 21.64 | –21.69 to 10.58 | –10.37 to 32.40 | –38.82 to 10.25 |
Note: ITT population with baseline measurable disease.
Abbreviations: BCL2, B-cell lymphoma 2; CBR, clinical benefit rate; CI, confidence interval; ITT, intention-to-treat.