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. 2022 May 18;28(15):3256–3267. doi: 10.1158/1078-0432.CCR-21-3811

Table 3.

CBR in BCL2-high, BCL2-low, PIK3CA-wild-type, and PIK3CA-mutant subgroups.

BCL2-high BCL2-low PIK3CA-wild-type PIK3CA-mutant
Venetoclax plus fulvestrant Fulvestrant Venetoclax plus fulvestrant Fulvestrant Venetoclax plus fulvestrant Fulvestrant Venetoclax plus fulvestrant Fulvestrant
n = 33 n = 33 n = 18 n = 18 n = 29 n = 31 n = 19 n = 14
CBR, n (%) 6 (18.2) 6 (18.2) 0 1 (5.6) 6 (20.7) 3 (9.7) 0 2 (14.3)
Risk difference (%) 0 –5.56 11.01 –14.29
95% CI –21.64 to 21.64 –21.69 to 10.58 –10.37 to 32.40 –38.82 to 10.25

Note: ITT population with baseline measurable disease.

Abbreviations: BCL2, B-cell lymphoma 2; CBR, clinical benefit rate; CI, confidence interval; ITT, intention-to-treat.