Table 2.
Cox-proportional hazard regression analysis for PFS.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (≤70/>70) | 1.10 (0.64–1.87) | 0.73 | ||
| Sex (male/female) | 1.25 (0.69–2.29) | 0.47 | ||
| Smoking history (yes/no) | 1.55 (0.75–3.18) | 0.23 | ||
| ECOG PS (0/1) | 0.73 (0.42–1.28) | 0.28 | ||
| Histology (non-Sq/Sq) | 0.45 (0.25–0.81) | 0.01 | 0.57 (0.31–1.05) | 0.07 |
| Stage (III, IV/recurrence) | 1.35 (0.72–2.53) | 0.35 | ||
| PD-L1 expression at diagnosis (<50%/≥50%) | 1.24 (0.89–1.70) | 0.59 | ||
| Response with prior ICI (CR, PR/SD ≥ 6 months) | 0.85 (0.48–1.49) | 0.56 | ||
| Duration of prior ICI (≤8.1 months/>8.1 months) | 1.83 (1.02–3.30) | 0.04 | 1.27 (0.68–2.38) | 0.46 |
| ICI-free interval (≤9.2 months/>9.2 months) | 2.61 (1.47–4.64) | 0.001 | 2.02 (1.10–3.73) | 0.02 |
| History of irAE with prior ICI (yes/no) | 0.51 (0.28–0.91) | 0.02 | 0.69 (0.37–1.29) | 0.24 |
Abbreviations: Non-Sq, non-squamous; PS, performance status; Sq, squamous.