FIG. 4.

Locomotor activity was measured as the total time per hour spent by mice on running in their cage, eating, drinking, and cleaning their fur and nest. Locomotor activity was recorded during a 24-h period 8 days postinfection for noninfected wild-type mice (A), T. brucei AnTat 1.1-infected wild-type mice (B), and infected TNF-α^−/− mice (C). Mice were kept in an animal facility with a 12-h-light–12-h-dark regimen. Three mice per experimental group were used, and the results are expressed as means ± standard deviation.