FIG. 6.

Survival after LPS challenge of noninfected (■) and T. brucei AnTat 1.1-infected (□) C57BL/6 wild-type mice (A) was compared to the survival after LPS challenge of noninfected (●) and infected (○) TNF-α^−/− mice (B). Mice were infected at day 0 by intraperitoneal injection of 5,000 parasites, and at day 14 postinfection, LPS was administered via intraperitoneal injection. LPS sensitivity was analyzed in an LPS dose range from 0.01 μg/mouse up to 10 mg/mouse in both infected and noninfected mice, with five mice used per LPS data point.