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. 2022 Nov 15;228(1):152302. doi: 10.1016/j.imbio.2022.152302

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Fig. 6 — (a) Domain organization of nsp7 and nsp8. Cartoon representation of SARS-CoV-2 nsp7 bound to the C-terminal of nsp8 in the lower-left panel (PDB: 6M5I). The lower-right panel shows protein–protein interactions between SARS-CoV-2 nsp7 and nsp8. (b) The overall topology of SARS-CoV-2 nsp12 with different colors domains. Cartoon representation in the below (left panel) shows SARS-CoV-2 nsp12-nsp7-nsp8 complex (PDB: 7BV2). The conserved zinc-binding motifs are highlighted in the SARS-CoV-2 nsp12 structure. The coordinate details of the zinc-binding residues are shown in stick representation. Protein-protein interactions between SARS-CoV-2 nsp12, nsp7, and nsp8 are shown in the left and right panels.