Table 1.

Patient history and treatment details (12-year-old, Male, Poodle); series of events in chronological order

Type of intervention	Details	Remarks
Pre-GDEPT
Surgery (lumpectomy)	(1) Lumpectomy of perineal mass; Also (2) had mass on jaw removed	Tumour samples were sent for histopathological analysis and confirmed to be (1) perianal adenoma and (2) acanthomatous ameloblastoma. Perianal mass was completely excised
Surgery (mandibulectomy)	Partial mandibulectomy was done	Routine consultation revealed oral acanthomatous ameloblastoma has grown; scheduled surgical consult with specialist for mandibulectomy
Surgery	Perineal mass recurred; had castration done as well	Castration was done to prevent recurrence

	Route of administration	Dosage of MSC_CD::UPRT::GFP (volume injected)	Oral 5-FC taken daily for 4 days (mg)	Patient weight (kg)	Quality of life observation
GDEPT treatment
GDEPT (cycle 1)	Intra-tumoral	1 × 107 cells (500 µL)	500	8.95	Tumour remained stable. No vomiting and diarrhea. Patient remained active and had good appetite
GDEPT (cycle 2)	Intra-tumoral	1 × 107 cells (500 µL)	500	9.2	Significant weight gain and increased fur growth. Less irritable. Significant decrease in tumour volume
GDEPT (cycle 3)	Intra-tumoral	1 × 107 cells (500 µL)	500	9.15	Tumour volume remained stable. Improved coat condition and fur growth. Patient remained active
Tumour progression observed 4 months post cycle 3
Surgical resection followed by GDEPT	Intra-cavity	3 × 107 cells (1000 µL)	500	–	22 months cancer free