Figure 6.

Cur prevented diabetes-induced bone loss and promoted vessel formation in vivo. (a) Experimental design illustrating the time points for inducing diabetes by STZ, establishing the DM model, and the timing of curcumin administration in the animal model. (b)–(g) Micro-CT images and (b) quantitative CT analysis (c)–(g) were performed in the distal femur from normal mice, DM mice, and DM mice treated with Cur. (h) Images of microfil perfusion. (i) Representative immunostaining images for CD31 (green) and EMCN (red) in the distal femur. (j) The Emcn^hi CD31^hi (yellow) cells were quantified. Data are shown as mean ± SD. ^∗p < 0.05 and ^∗∗p < 0.01 versus CON group. ^#p < 0.05 and ^##p < 0.01 versus DOP group.