TABLE 2.
Summary of evidence
| Study characteristics | Outcomes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Author | Year | Study Type | Population | Rate of major bleeding with LMWH | Rate of major bleeding without LMWH | Rate of minor bleeding with LMWH | Rate of minor bleeding without LMWH | Rate of VTE with LMWH | Rate of VTE without LMWH | Rate of fatal VTE without LMWH | Rate of fatal VTE with LMWH | Comments |
| Rausa 39 | 2018 | Meta‐analysis |
Postoperative patients n = 1525, 649 extended‐duration thromboprophylaxis, 641 conventional |
1.37 (RR) | — | 1.42 (RR) | 1.2 (RR) | 0.47 (RR) | — | — | — | — |
| Pannucci 14 | 2017 | Meta‐analysis | 11 studies, n = 14,776 contained risk‐stratified VTE data, 8 studies | — | — | — | — | — |
3–4: 0.7% 5–6: 1.8% 7–8: 4.0% >8: 10.7% |
— | — | VTE rate stratified by Caprini score |
| Douketis 40 | 2007 | Prospective cohort | 2052 patients who recently discontinued anticoagulation | — | — | — | — | — | — | 0.002% | — | — |
| Lyman 12 | 2021 | American Society of Hematology 2021 guidelines | — | — | 1.0 (RR) | — | — | — | — | — | — | — |
Abbreviation: RR, Risk Ratio.