TABLE 1.

Natural products regulate glycolytic enzymes in cancer.

Ingredients	Target glycolytic enzymes	Adjustment method	Tumor	Source	Category	References
emodin	GLUT1	down-regulate	renal cell carcinoma	rhubarb	anthraquinone	Wang et al. (2021a)
cucurbitacin D	GLUT1	down-regulate	prostate cancer	cucurbitaceae	tetracyclic triterpenoid	Sikander et al. (2019)
Saponin monomer 13 of the dwarf lilyturf tuber	GLUT1	down-regulate	colorectal cancer	dwarf lilyturf tuber	saponin monomer	Wei et al. (2019)
phenethyl isothiocyanate	GLUT1 HK2	down-regulate	prostate cancer	cruciferous vegetables	isothiocyanate	Singh et al. (2018)
genistein	GLUT1, HK2	down-regulate	hepatocellular carcinoma	soy products	isofavonoid	Li et al. (2017)
parthenolide	GLUT1 HXK II	down-regulate	colorectal cancer	extracts of Mexican Indian medicinal plants	sesquiterpene lactone	Kim et al. (2017)
physciosporin	GLUT1, HK2, PKM2	down-regulate	breast cancer	species of genus Pseudocyphellaria	depsidone	Taş et al. (2021)
α-Hederin	GLUT1, HK2, PKM2, LDHA	down-regulate	lung cancer	pulsatilla chinensis	pentacyclic triterpenoid saponin	Fang et al. (2021a)
oleuropein	GLUT1, PKM2	down-regulate	melanoma	olea europaea L	phenolic	Ruzzolini et al. (2020)
cantharis	GLUT1, PKM2	down-regulate	breast cancer	insect	cantharidin	Pan et al. (2019b)
tetracyclic quinazine compounds	GLUT1, PKM2	down-regulate	colorectal cancer	root of sophora flavescens ait	oxymatrine	Li et al. (2020b)
morusin	HK2, PKM2, LDH	down-regulate	hepatocellular carcinoma	the roots of morus alba	flavonoid	Cho et al. (2021)
quercetin	GLUT1, PKM2, LDHA	down-regulate	breast cancer	Leaves, fruits, vegetables	flavonoid	Jia et al. (2018)
β-elemene	GLUT1, PKM2, LDHA	inhibit	breast cancer	curcuma zedoary	terpene	Pan et al. (2019a)
licochalcone A	GLUT1, PDK1	down-regulate	hypoxic cancer	gycyrrhiza uralensis	phenol chalconoid	Park et al. (2021b)
tanshinone IIA	HK2	down-regulate	oral squamous cell carcinoma	salvia miltiorrhiza	diterpenoid naphthoquinone	Li et al. (2020a)
dioscin	HK2	down-regulate	colorectal cancer	plants	steroidal saponin	Zhou et al. (2020)
triptolide	HK2	down-regulate	non-small cell lung cancer	root extracts of tripterygium wilfordii	pentacyclic triterpenoid	Hamdi et al. (2018)
rhein	HK2	inhibit	Liver cancer cell	rheum palmatum	monomeric anthraquinone	Wu et al. (2019)
sulforaphane	HK2, PK	down-regulate	prostate cancer	broccoli extract	isothiocyanate	Carrasco-Pozo et al. (2019)
oleanolic acid	HK2, PFK1	down-regulate	gastric tumor cell	leaves and roots of oleaceae plants	pentacyclic triterpenoid saponin	Li et al. (2019)
compound K	HK2, PKM2	down-regulate	hepatocellular carcinoma	saponin	a metabolite of the ginsenosides	Shin et al. (2021)
dauricine	HK2, PKM2	down-regulate	hepatocellular carcinoma	roots of Menispermm dauricum D.C.	alkaloid	(Jin et al., 2010; Li et al., 2018d)
epigallocatechin gallate	PFK	down-regulate	colorectal cancer	green tea	polyphenol	Chen et al. (2022a)
kaempferol	PKM2	down-regulate	colon cancer	natural foods	polyphenol	Wu et al. (2021)
tannic acid	PKM2	down-regulate	colon cancer	grapes and green tea	polyphenolic acid	Yang et al. (2018)
proanthocyanidin B2	PKM2	down-regulate	hepatocellular carcinoma	grape seed, pine bark, wine, and tea leaves	dimer flavonoid	Feng et al. (2019)
isovitexin	PKM2	down-regulate	non-small cell lung cancer	food byproducts and medicinal plants	flavonoid	Chen et al. (2021a)
pachymic acid	PKM2	down-regulate	breast cancer	poria cocos	triterpenoid	Miao et al. (2019)
Parthenolide derivative	PKM2	down-regulate	glioblastoma	feverfew	germacrane sesquiterpene lactone	Ding et al. (2020)
Shikonin	PKM2	inhibit	bladder cancer	lithospermum erythrorhizon	naphthoquinone analog	Wang et al. (2018)
Curcumin	PKM2	down-regulate	lung cancer	rhizome of the plant curcuma longa	phyto polyphenol	Siddiqui et al. (2018a)
Lapachol	PKM2	down-regulate	melanoma	the bark of tabebuia avellanedae	analog of shikonin	Shankar Babu et al. (2018)
Micheliolide	PKM2	down-regulate	leukemia	michelia champaca plants	guaianolide sesquiterpene lactone	Li et al. (2018c)
diallyl disulfide	PKM2	down-regulate	breast cancer		sulfur-containing organic	Xie et al. (2018)
Gliotoxin	PKM2	down-regulate	glioma	marine-derived fungal secondary metabolite	sulfur-containing organic	Tang et al. (2020)
Shikonin	PKM2	down-regulate	lung carcinoma	lithospermumn erythrorhizon	naphthoquinone	Zhao et al. (2018)
capsaicin	PKM2, LDHA	down-regulate	sepsis	capsicum	isothiocyanate	Zhang et al. (2022a)
Catechin	LDHA	down-regulate	gastric cancer	green tea	polyphenol	Han et al. (2021)
epigallocatechin gallate	LDHA	down-regulate	breast and pancreatic cancer	green tea	polyphenol	Lu et al. (2015)
astragaloside IV	LDHA	down-regulate	gastric carcinoma	astragalus membranaceus	triterpenoid saponin	Zhang et al. (2018)
betulinic acid	LDHA, p-PDK1, PDK1	down-regulate	breast cancer	birch bark	pentacyclic terpene	Jiao et al. (2019a)
Scopolin	PGK2, GPI, GPD2	inhibit	hepatocellular carcinoma	smilax china L	alkaloid	Wang et al. (2022)
cardamonin	PDHK1	down-regulate	breast cancer	alpinia katsumadai	chalcone	Jin et al. (2019a)
Erianin	pyruvate carboxylase	inhibit	cancers	plants of the genus dendrobium	dibenzyl compound	Hong et al. (2022)