TABLE 2.

Natural products regulate glycolysis through the PI3K-AKT-mTOR signaling pathway in cancer.

Ingredients	Target	Adjustment method	Target tumor	Source	Category	References
resveratrol	PI3K, AKT, mTOR	down-regulate	cancers	grapes, berries, peanuts, red wine	polyphenol	Brockmueller et al. (2021a)
salvianolic acid B	PI3K, AKT	down-regulate	oral squamous cell carcinoma	salviae miltiorrhizae	polyphenol	Wei et al. (2018b)
Shikonin	PI3K/AKT	inactivate	nasopharyngeal carcinoma	root of the herbal plant	naphthoquinone	Zhang et al. (2020)
Emodin	PI3K, AKT	down-regulate	renal cell carcinoma	Rhubarb	anthraquinone	Wang et al. (2021a)
triptolide	AKT, mTOR	down-regulate	non-small cell lung cancer	root extracts of tripterygium wilfordii	pentacyclic triterpenoid	Hamdi et al. (2018)
atractylenolide I	AKT, mTOR	down-regulate	colorectal cancer	plant-based baizhu	sesquiterpenoids	Wang et al. (2020)
tanshinone IIA	AKT	down-regulate	oral squamous cell carcinoma	salvia miltiorrhiza	diterpenoid naphthoquinone	Li et al. (2020a)
compound K	AKT, mTOR	down-regulate	hepatocellular carcinoma	Saponin	metabolite of the ginsenoside	Shin et al. (2021)
Morusin	AKT mTOR	down-regulate	hepatocellular carcinoma	the roots of morus alba	flavonoid	Cho et al. (2021)
Berberine	mTOR	down-regulate	colon cancer	roots, rhizomes, stems, and bark of berberis plan	isoquinoline alkaloid	Mao et al. (2018a)
curcumin	mTOR	down-regulate	lung cancer	rhizome of the plant curcuma longa	polyphenol	Siddiqui et al. (2018a)
lily saponin monomer 13	mTOR	down-regulate	colorectal cancer	dwarf lilyturf tuber	saponin monomer	Wei et al. (2019)