TABLE 4.

Natural products regulate glycolysis via oncogenes in cancer.

Ingredients	Target glycolysis	Adjustment method	Target tumor	Source	Category	References
betulinic acid	c-MYC	down-regulate	breast cancer	birch bark	pentacyclic terpene	Jiao et al. (2019a)
compound K	c-MYC	down-regulate	hepatocellular carcinoma	saponin	a metabolite of the ginsenosides	Shin et al. (2021)
astragalus saponins	c-MYC	down-regulate	colorectal cancer	medicinal herb radix astragali	total saponin	Guo et al. (2019)
tanshinone IIA	c-MYC	down-regulate	oral squamous cell carcinoma	diterpenoid naphthoquinone	salvia miltiorrhiza	Li et al. (2020a)
Morusin	c-MYC	down-regulate	hepatocellular carcinoma	the roots of Morus alba	flavonoid	Cho et al. (2021)
phenethyl isothiocyanate	c-MYC	down-regulate	prostate cancer	cruciferous vegetables	isothiocyanate	Singh et al. (2018)
salvianolic acid B	HIF-1α	down-regulate	oral squamous cell carcinoma	salviae miltiorrhizae	polyphenol	Wei et al. (2018b)
licochalcone A	HIF-1α	down-regulate	hypoxic cancer	glycyrrhiza uralensis	phenol chalconoid	Park et al. (2021b)
curcumin	HIF-1α	down-regulate	lung cancer	rhizome of the plant Curcuma longa	phyto polyphenol	Siddiqui et al. (2018a)
Baicalein	HIF-1α	down-regulate	tamoxifen-resistant breast cancer	Scutellaria baicalensis	Polyphenol	Chen et al. (2021a)
oleanolic acid	HIF-1α	down-regulate	gastric tumor cell	leaves and roots of oleaceae family plants	pentacyclic triterpenoid saponin	Li et al. (2019)
Deoxypodophyllotoxin	HIF-1α	down-regulate	non-small cell lung cancer	anthriscus sylvestris (L.) Hoffm	natural lignans	Yang et al. (2021)
parthenolide	HIF-1 a	down-regulate	colorectal cancer	extracts of Mexican Indian medicinal plants	sesquiterpene lactone	Kim et al. (2017)
astragaloside IV	HIF-1α	down-regulate	gastric carcinoma	astragalus membranaceus	triterpenoid saponin	Zhang et al. (2018)
cardamonin	HIF-1α	down-regulate	breast cancer	alpinia katsumadai	chalcone	Jin et al. (2019a)
berberine	HIF-1α	down-regulate	colon cancer	roots rhizomes stems, bark of Berberis plan	isoquinoline alkaloid	Mao et al. (2018a)
resveratrol	HIF-1α/ROS	down-regulate	Cancers	grapes, berries, peanuts, red wine	polyphenol	Brockmueller et al. (2021a)
astragaloside IV	p53	up-regulate	gastric carcinoma	astragalus membranaceus	triterpenoid saponin	Zhang et al. (2018)