TABLE 5.

Natural products regulate glycolysis through the lasted signal pathway in cancer treatment.

Ingredients	Target glycolysis	Adjustment method	Target tumor	Source	Category	References
α-Hederin	SIRT6	active	lung cancer	pulsatilla chinensis	pentacyclic triterpenoid saponin	Fang et al. (2021a)
scopolin	PGK2 GPI GPD2	inhibit	hepatocellular carcinoma	smilax china L	alkaloid	Wang et al. (2022)
1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose	GAPDH	inhibit	glioblastoma multiforme	plants	a tannin family compound	Ding et al. (2020)
parthenolide	PKM2	active	colorectal cancer	extracts of Mexican Indian medicinal plants	sesquiterpene lactone	Liu et al. (2021b)
Dioscin	Skp2	down-regulate	colorectal cancer	plants	steroidal saponin	Zhou et al. (2020)
Bufalin	ITGB2/FAKs pathway	inhibit	ovarian cancer	traditional Chinese medicine Chansu	major digoxin-like component	Li et al. (2018d)
berberine	miR-145	up-regulate	colon cancer	roots rhizomes stems, bark of Berberis plan	isoquinoline alkaloid	Li et al. (2021)
Astragaloside IV	MCT1 MCT4 CD147/miRNA-34a TIGAR	down-regulate	gastric carcinoma	A.membranaceus	a marker for the active constituent	Zhang et al. (2018)
oviductus ranae	miR-491-5p PKM2	down-regulate	hepatocellular carcinoma	dried oviduct of mature female Rana dybowskii	traditional animal-based medicine	Xu et al. (2018)
Curcumin	GLUT 1 PKM LDHA AKT	down-regulate	liver cancer	rhizome of the plant curcuma longa	phyto polyphenol	Man et al. (2020)
Curcumin	P53	up-regulate	liver cancer	rhizome of the plant curcuma longa	phyto polyphenol	Man et al. (2020)
Resveratrol	PKM2	down-regulate	melanoma	grapes, berries, peanuts, red wine	polyphenol	Jia et al. (2021)
Resveratrol	AMPK	up-regulate	melanoma	grapes, berries, peanuts, red wine	polyphenol	Jia et al. (2021)
1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose	GAPDH	inhibit	colon cancer	natural plants	tannin family compound	Li et al. (2022b)