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. 2022 Nov 14;13:6949. doi: 10.1038/s41467-022-34266-w

Fig. 5. Computational simulation of long bone shaping during development and regeneration.

Fig. 5

A Differences in shape between normally developing (left) and regenerated (right) limb cartilages of the larval Pleurodeles waltl. B Long bone represented by a 3D cylinder. The geometrical and material properties used are specified. C Tissue growth is described as region-specific internal pressures. Tissues are subdivided into different regions, as shown in the scheme (B). Two configurations of internal pressures are applied for modelling normal growth (left) and regeneration (right). D Snapshots of the internal tissue growth simulation for the development (left) and regeneration (right) of the long bone shape.