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. 2022 Nov 14;13:6942. doi: 10.1038/s41467-022-34574-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overall topology of Ca²⁺ binding sites is shown for a single subunit of IP₃R1 (white ribbon) with the region surrounding the Ca²⁺ binding site highlighted in the corresponding domain color: Ca-I_LBD and Ca-II_LBD sites in the ligand binding domains (blue/turquoise); Ca-III_s site in the Ca²⁺ sensor region located within the ARM3 domain (lime green/orange); Ca-IV_L and Ca-V_L sites in luminal vestibule of the TMD (purple). b Zoomed-in views of the Ca²⁺ binding sites. Ca²⁺ ions are shown as green spheres and overlaid with corresponding densities displayed at 2-5 σ cutoff values. Residues within 5 Å of the Ca²⁺ ions are displayed in a stick representation and labeled.