Table 2.
Donor baseline characteristics for the study cohorts.
| N | Ext. validation 2017–2018 N = 4750 |
Test 2014–2016 N = 6120 |
Train/val. 1987–2013 N = 31,315 |
Test statistic | |
|---|---|---|---|---|---|
| Donor age (yrs)*,† | 42,185 |
24 31 40 33 ± 11 |
23 31 41 32 ± 11 |
21 30 42 32 ± 12 |
F2 42182 = 18, P < 0.0012 |
| Donor female gender* | 42,185 | 30%1443⁄4750 | 30%1828⁄6120 | 29%9214⁄31,315 | χ22 = 2.1, P = 0.361 |
| Donor height (cm)* | 42,144 |
168.0 175.0 180.3 174.0 ± 9.6 |
167.6 175.0 180.3 173.8 ± 9.6 |
167.6 175.3 182.9 174.6 ± 9.5 |
F2 42141 = 19, P < 0.0012 |
| Donor weight (kg)* | 42,179 |
70 81 95 84 ± 19 |
70 80 93 83 ± 20 |
68 79 90 81 ± 18 |
F2 42176 = 69, P < 0.0012 |
| Donor ABO blood type* | 42,184 | χ26 = 7.7, P = 0.261 | |||
| A | 36.7%1745⁄4750 | 35.3%2163⁄6120 | 36.4%11,413⁄31,314 | ||
| AB | 2.1%99⁄4750 | 2.5%154⁄6120 | 2.3%706⁄31,314 | ||
| B | 10.9%520⁄4750 | 11.3%690⁄6120 | 10.5%3295⁄31,314 | ||
| O | 50.2%2386⁄4750 | 50.9%3113⁄6120 | 50.8%15,900⁄31,314 | ||
| Donor cause of death* | 42,149 | χ28 = 2669, P < 0.0011 | |||
| Anoxia | 38.2%1813⁄4748 | 29.8%1823⁄6118 | 12.3%3850⁄31,283 | ||
| Cerebrovascular/stroke | 14.8%703⁄4748 | 19.1%1166⁄6118 | 25.6%8000⁄31,283 | ||
| CNS tumor | 0.5%23⁄4748 | 0.3%21⁄6118 | 1.0%313⁄31,283 | ||
| Head trauma | 44.6%2119⁄4748 | 48.6%2971⁄6118 | 59.3%18,544⁄31,283 | ||
| Other | 1.9%90⁄4748 | 2.2%137⁄6118 | 1.8%576⁄31,283 | ||
| Ischemic time (min)*,† | 40,394 |
138 184 223 183 ± 64 |
143 186 227 187 ± 62 |
146 188 229 190 ± 63 |
F2 40391 = 23, P < 0.0012 |
| Recipient-donor height ratio* | 42,037 |
0.963 1.000 1.036 1.000 ± 0.056 |
0.967 1.000 1.040 1.002 ± 0.057 |
0.958 1.000 1.036 0.998 ± 0.061 |
F2 42034 = 16, P < 0.0012 |
| Recipient-donor weight ratio* | 42,086 |
0.87 1.03 1.18 1.03 ± 0.23 |
0.88 1.02 1.17 1.03 ± 0.22 |
0.88 1.02 1.16 1.02 ± 0.21 |
F2 42083 = 2.6, P = 0.0712 |
a b c represents the lower quartile a, the median b, and the upper quartile c for continuous variables. x ± s represents X ± 1 SD. N is the number of non-missing values. Variables included in * IHTSA, # IMPACT, and † PRN model. CNS, Central nervous system tumours. Tests used: 1Pearson test; 2Kruskal–Wallis test.