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. 2022 Nov 1;13:1037563. doi: 10.3389/fphar.2022.1037563

TABLE 2.

Results of metabolic pathway analysis.

No. Pathway name Hits −log(p) Impact Metabolites
1 Pentose and glucuronate interconversions 1 5.69 0.14 6-Hydroxy-5-methoxyindole glucuronide
2 Arginine and proline metabolism 1 5.02 0.08 1-Pyrroline-5-carboxylic acid
3 Folate biosynthesis 1 4.95 0.07 Tetrahydrobiopterin
4 Glycine, serine and threonine metabolism 2 3.50 0.29 Dimethylglycine; L-Serine
5 Arginine biosynthesis 1 3.26 0.23 Citrulline
6 Steroid hormone biosynthesis 1 2.15 0.03 Estradiol
7 Glycerophospholipid metabolism 4 2.07 0.36 LysoPA (0:0/16:0); PC[15:0/18:4 (6Z,9Z,12Z,15Z)]; PE [14:0/20:5 (5Z,8Z,11Z,14Z,17Z)]; LysoPC(15:0)