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. 2022 Nov 1;12:1012028. doi: 10.3389/fcimb.2022.1012028

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Copyright © 2022 Chen, Tang, Ye, Yu, Yang, Cheng, Zhang and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alteration of Taxonomic Composition in MHO Mice. (A) Experimental design of mice. (B) Metabolic parameters of body weight (B) and IPGTT (C) were examined at the beginning of the 9th week. (D) Alpha diversity was evaluated by observed Richness, Shannon index, Simpson index, and Chao1 using the Student’s t-test. (E) PCoAs of β-diversity with the 3-dimensional presentation. (F) Firmicutes/Bacteroidetes ratio was compared using the Mann-Whitney U test between MHO and controls. (G) Heatmap visualization of the top 30 abundant species in MHO and controls. (H) Manhattan plots showing the changed composition of species in MHO by the edgeR algorithm. The color of each dot represents the different taxonomic affiliations of the species (phylum level), and the size corresponds to their relative abundance. The Y-axis represents log counts per million(CPM). The upward-pointing triangle indicates enriched species, whereas the downward-pointing triangle represents depleted ones. * p 0.05 ** p 0.01 *** p 0.001.