Skip to main content
. 2022 Oct 27;8(11):e11194. doi: 10.1016/j.heliyon.2022.e11194

Figure 7.

Figure 7

HFD conceptual model. (1a) An HFD (unsaturated fat) produces an increase in Bacteroides abundance and also the gut increasing Free Fatty Acids (FFA) in the blood absorbs (1b). (2) Bacteroides digest the mucins in the host when low levels of starch are present (as found in the HFD). (3) Toxins from the Bacteroides decrease tight junction mRNA levels promoting the entry of LPS (represented by black dots) to the peripheral system. (4) Circulating LPS and FFA increases adiposity and leptin levels, and possibly activates microglia in a TLR4 dependent manner. (5) TLR4 pathway produces inflammation in the brain by cytokines. (6) Brain inflammation produces behavioral despair.