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. 2022 Nov 1;10:1033348. doi: 10.3389/fcell.2022.1033348

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Copyright © 2022 Nuevo-Tapioles and Philips.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KRAS4A regulates hexokinase 1 catalytic activity. Hexokinase 1 (HK1) is resident on the outer mitochondrial membrane (OMM) owing to an N-terminal targeting sequence. KRAS4A undergoes a cycle of palmitoylation/depalmitoylation on cysteine 180 that drives association with the plasma membrane or OMM, respectively. KRAS4A interacts with HK1 on the OMM in a GTP-dependent fashion and stimulates HK1 activity by limiting the allosteric feedback inhibition physiologically mediated by glucose-6-phosphate.