Figure 5.

Pyroptosis pathway. Depending on whether pyroptosis requires caspase-1 activation, it can be divided into the classical and non-classical inflammasome pathways. ASC, apoptosis-associated speck-like protein, ER endoplasmic reticulum, GSDMD Gasdermin D, HMGB1 high mobility group box 1, IL-1β interleukin-1β, IL -18 interleukin- 18, MyD88 myeloid differentiation primary response gene 88, NLRP3 NLR-family pyrin domain-containing protein 3NF-κB nuclear factor kappa B, NLRP3 NLR-family pyrin domain-containing protein 3, ox-LDL oxidized low density lipoprotein, ROS reactive oxygen species, TLR Toll-like receptors.