FIGURE 7.

Correlation between five clinical drugs treated response and two key biomarkers expression levels in colon cancer. (A) Patients who responded to 5‐fluorouracil, irinotecan and oxaliplatin had significantly higher levels of BGN expression than those who did not responded. AUC and p value of ROC of BGN high expression level in treatment with five drugs and 5‐fluorouracil, irinotecan and oxaliplatin have well efficacy. (B) Patients who responded to 5‐fluorouracil and irinotecan had significantly higher levels of THBS2 expression than those who did not responded. AUC and p value of ROC of THBS2 high expression level in treatment with five drugs and 5‐fluorouracil and irinotecan have well efficacy. (C) Effects on proliferation of stably transfected sh‐BGN cell lines after treated with 5‐fluorouracil, irinotecan and oxaliplatin. (D) Effects on proliferation of stably transfected sh‐THBS2 cell lines after treated with 5‐fluorouracil and irinotecan