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. 2022 Nov 15;12:19547. doi: 10.1038/s41598-022-23793-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Boxplots depict (A) age, (B) Center for Epidemiological Studies Depression Scale (CES-D) total score, and (C) Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) total score across women who were diagnosed with and undergoing chemotherapy treatment for breast cancer (BC) and healthy controls (HC). Boxes represent the first and third quartiles, and horizontal lines within boxes represent median values. Whiskers represent non-outlier high and low values, and diamonds represent outliers as defined by having a value greater than 1.5 times the interquartile range (IQR) of the first or third quartile. In (B), lower FACT-Cog values in BC indicate more cognitive difficulties, and in (C), higher CES-D scores in BC indicate higher depressive symptoms.