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. 2022 Nov 15;12:19547. doi: 10.1038/s41598-022-23793-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Linear discriminant analysis Effect Size (LEfSe) scores for taxa identified to be enriched in individuals with high perceived cognitive impairments scores (FACT-Cog < 60) relative to participants with low cognitive impairment as assessed by FACT-Cog perceived cognitive impairments subscales. LEfSe Scores are given as the logarithm (base 10) of their importance score for linear discriminant analysis (LDA). Higher absolute values of the LEfSe scores indicate stronger enrichment in their respective groups. Positive values on the x axis indicate enrichment in participants with high cognitive impairment scores, whereas negative values indicate enrichment in participants with low cognitive impairment scores. Color represents the phylum of each taxon identified. C, class; O, Order; F, family; G, genus.