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. 2022 Nov 15;12:19547. doi: 10.1038/s41598-022-23793-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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A scatterplot with a fitted linear model shows Center for Epidemiological Studies Depression Scale (CES-D) total score as a function of participants’ microbiome’s Faith’s phylogenetic diversity. Each dot represents the participant’s CES-D score in relation to the alpha diversity of the participant’s fecal microbiome sample. A high CES-D score indicates higher depression symptom severity. The solid line represents the line of best fit, and the shaded area represents a 95% confidence interval.